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08 Abril 2018, 11:11 | Gerardo Tarin
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Welbeck missed a glorious chance from just yards out when Jack Wilshere had stretched to keep a move alive but he made no mistake shortly after with a back-post header following more fine work by Iwobi.
Goalscorer Charlie Austin echoed his manager's frustration.
The 17th placed team were looking the more unsafe in front of goal, and in the 17th minute, Cedric Soares played a ball into the box from the right, Shane Long was more alert than Mustafi and produced a clever finish past Petr Cech in the Arsenal goal to give Southampton a precious lead.
Yet the opening goal only served to kick-start Wenger's side out of their slumbering state.
Welbeck then cut inside onto Alex Iwobi's pass to give Arsene Wenger's side a barely-deserved halftime lead. The comprehensive victory over CSKA Moscow earlier in the week has put Arsenal in a decent position to go all the way in the Europa League this season but they will certainly have one eye on finishing the domestic league season on a strong note.
Arsenal sit sixth in the table, five points behind Chelsea and two ahead of Burnley, and they have won their last five games.
Saints' chances were limited, but Elneny had to be on hand to clear off the line as Wesley Hoedt sent a header towards goal with Cech scrambling to tip a Long header behind soon after.
Just as Southampton were preparing to take a free-kick, Elneny was seen shoving out at Cedric Soares and he too was shown a straight red.
The England striker was in good form from the start against the north London side as he played a part in all three goals.
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