Vincenzo Montella and his Sevilla players travel to Manchester United with a Champions League quarter-final place the prize if they can win on Tuesday.
Mourinho confirmedDaley Blind, Marcos Rojo, Ander Herrera and Phil Jones are all injured and will play no part against Sevilla.
Alexis Sanchez was the first out for training on a rainy day at Carrington as the Chilean prepares for Manchester United's clash with Sevilla on Tuesday night. Find us on Facebook too!
Chelsea fans serenaded their former boss with chants of "just like London, your city is blue" on their visit to Old Trafford last month. United enter the game on the back of a morale-boosting run of three consecutive wins in the Premier League.
"Looking at the first-leg team, his [Mourinho's] side had very offensive players like [Alexis] Sanchez, [Romelu] Lukaku, et cetera". They got the result, now they're at home.
The Danish defender is expected to slot into his natural position in central defence with Argentine worldwide Gabriel Mercado moving to right-back.
"But in the moment I can not, and I don't want to, think about anything else".
"We are hoping to do something exhilarating at Old Trafford after not scoring a goal that we deserved in the opening leg", Sevilla president Pepe Castro told Radio Sevilla FC.
Sevilla have also been beaten in the league 11 times already this campaign, six more than their tally at the same stage of last season.
Despite the evidence suggesting United lose more often with Pogba starting than they do when he's out of the team, Mourinho will undoubtedly want the club's record signing at his disposal against Sevilla.
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