City's visit will provide evidence of whether Liverpool can cope without Philippe Coutinho following the Brazil forward's sale to Barcelona.
But Liverpool, on their current run, with their new centre-back at long last, desperate for a morale-boosting result following a week of soul-searching on Merseyside, may give City their biggest scare yet.
He is one of the best players in the Premier League in his position.
Liverpool are unbeaten in 17 matches in all competitions, their best run under Jurgen Klopp, since losing to Tottenham on 22 October.
Manchester City manager Pep Guardiola revealed on Friday that the club's Brazilian striker, Gabriel Jesus, will be fit for the Champions League game against Basel. But since that fateful meeting in September, Liverpool have more than fine tuned their own engine and the players will have all the confidence and determination they need to right the wrongs of the Etihad debacle.
"It is a real test going to Anfield, one of most prestigious stadiums and teams in the world", Guardiola stated in his pre-match press conference. "It is a game for us and we are going to plan as much as possible to know what is going to happen".
City's style of play could also prove telling down the line.
The Spanish left back has been absent from action for Liverpool since he got injured against Spartak Moscow in December.
It remains to be seen whether Liverpool FC will indeed make any more signings this month but Murphy clearly believes that a midfielder should be Klopp's priority in the mid-season transfer window.
Kevin #De Bruyne has been central to the Citizens' success so far this campaign, with the playmaker in the form of his life. "But the City game is a completely different game".
Any potential slip up by the champions elect will leave the door open for the Red Devils, who host managerless Stoke City on Monday evening.
City'sdefence have not been challenged like that this season. Chelsea has totally dominated this head-to-head series in recent years with a 12-1-1 record in its last 14 games against Leicester.
One could argue that City have already overcome their two potentially hardest games - the Old Trafford trip and the defeat of Chelsea at Stamford Bridge - but they are by no means clear of big games. Questions remain about his suitability for this Liverpool team.
Oklahoma health officials say flu death toll is 22
Because the flu is so bad this season, Chen says health professionals are doing things a bit differently this year. It takes about two weeks for the flu shot to take effect. "It's something we don't fully understand", said Strang.
Alabama back on top
Of course, every team aside from the celebrating Crimson Tide and grieving Bulldogs are already starting to focus on next season. Just over half of all Georgia football players graduated according to the most recent data available on the NCAA website .
Cold and ice make a return to the QC
If you are traveling north towards Nashville expect road conditions to deteriorate the closer you get to the Nashville area. The rain chance will stick around and last through the overnight hours and into Friday afternoon.
Australia Wins The Ashes
England's tour couldn't have gone much worse, relinquishing the Ashes after just three Tests and showing little fight throughout. Broad made 31 off 32 balls with a boundary and two sixes before mistiming a sweep shot to be caught by Smith off Lyon (1-86).