Murray beat 53rd-ranked Karen Khachanov of Russian Federation 6-3, 6-4, 6-4 on Court Philippe Chatrier while Wawrinka got the better of World No.15 Gael Monfils 7-5, 7-6 (7), 6-2 on Monday.
For the fourth year in succession, Murray is through to the last four of the French Open, his latest passage to the semi-finals coming courtesy of a four-set victory over Nishikori on Court Philippe Chatrier.
"I think today was probably the best I have played overall", said the top seed, who will face eighth seed Kei Nishikori in the quarter-finals.
"How the players are supposed to know that in their head when we're playing at one speed throughout the whole year, and then you show up at the slams, you're expected to speed up by 5 seconds".
Paris - Tennis legends John McEnroe and Goran Ivanisevic reckon Andy Murray has a good chance of making the final at Roland Garros.
"I played well, was very solid and took my opportunities". I also think when he played the French Open final here with Novak Djokovic, he played extremely well. "He was really aggressive, pushing me all the time, so it was tough for me to find a solution".
Nishikori said of the scoreline: "It's a little bit unusual".
Pliskova reached the U.S. Open final a year ago, but the Czech player had never been past the second round at Roland Garros in five previous appearances.
In four previous matches on clay, Simon Halep had never been able to beat Carla Suarez Navarro.
"Well, obviously the way I turned the match around, it was not a good first set", Murray said. There was so many long rallies, second and third sets.
Wawrinka was surprised to see the sixth seed win so easily, particularly picking up a bagel in the third set against the reigning champion.
'He was playing better. "He had some injury problems and was a little bit sick so he couldn't practise as much as he needs to in order to be ready, especially on clay". I think he started really well, the court bounces really high today and he was using a very heavy forehand and I was running side to side.
He might need another level, however, against Swiss former champion Wawrinka, who annihilated Marin Cilic 6-3 6-3 6-1.
- Second seed Karolina Pliskova came back from a set down to claim a 2-6 6-3 6-4 win over Paraguayan Veronica Cepede Royg.
Pakistan stun India to win Champions Trophy final
He celebrated with an extravagant twirl of his bat and kissed the turf as the Pakistan supporters sensed an unlikely win. His transformation into a hero was complete as his final tally was six overs, two maidens, 16 runs and three wickets.
The US Open: 5 Things to Watch on Sunday
Open's final round on Sunday as heavy winds pummeled the layout, adding an intriguing wrinkle to the year's second major. The tournament was never really in doubt after that, though the wind arrived and Kaymer couldn't maintain the pace.
Kite looks back on windy final round at Pebble
The 30-year old Harman fired six birdies and just one bogey, only his second dropped shot of the week in an impressive round. Open but still surrendered the third-round lead to fellow American Brian Harman on a helter-skelter Saturday at Erin Hills.
Ronaldo tells teamates about REAL exit?
But Real Madrid , the two-time defending European champion, won't allow Ronaldo to dictate terms of his potential exit. However, nothing is for sure at the moment as it won't be a big surprise if Ronaldo decides to stay put at Real.
Bacsinszky downs French favourite Mladenovic
Still, it was clear that she was up to the task against the 11th-seeded Wozniacki, who is 26 and has been to two U.S. While Wozniacki has been there and done it before, Ostapenko is just 20 years of age and ranked at 47 in the world.
Amir, Fakhar lead Pakistan to Champions Trophy triumph
The left-arm pacer extracted movement both in the air and off the pitch and quite a few of his deliveries were nearly unplayable. By the time Pandya was run out in the 27th over following a terrible mix-up, the match was as good as done and dusted.
Arnold Palmer's 1960 US Open win honored at Erin
Johnny Miller owned the previous best round of eight-under 63 set en route to victory in the final round at the 1973 U.S. Someone can get out early and shoot a low score. "What I've done this week is unbelievable ", Koepka .